IMAGE

Fig. S5

ID

ZDB-IMAGE-161027-14

Genes

elavl3

Publication

Cox et al., 2016 - Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

All Figures

Figures for Cox et al., 2016

Image

Figure Caption

Fig. S5

The seph mutant phenotype is partially mitigated by loss of p53. (A) WISH analysis of elavl3 (neurons) expression and Alcian blue staining in WT, seph^-/-, and tp53^-/-;seph^-/- mutant larvae at 5 dpf. (Scale bar: 200 µm.) (B) qPCR expression analysis of the neuron-specific gene elavl3 in WT, tp53^-/-, and tp53^-/-;seph^-/- mutant larvae at 5 dpf. n = 3. **P < 0.01. (C) Immunohistochemical detection of PCNA (proliferation) from transverse sections from WT, seph^-/-, and tp53^-/-;seph^-/- mutant larvae at 5 dpf. (Scale bar: 50 µm.) (D) Immunohistochemical detection of cleaved caspase-3 (apoptosis) from transverse sections from WT, seph^-/-, and tp53^-/-;seph^-/- mutant larvae at 5 dpf. (Scale bar: 50 µm.)

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA