ZFIN Image: Veldman et al., 2015, Fig. 5

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Fig. 5

Neuron specific activation of mHTT-ΔN17-exon1 causes motor behavioral phenotype. a elavl3:cre (n = 23), b gfap:cre (n = 24), c mylpfa:cre (n = 34), and d etv2:cre (n = 21) transgenic lines were incrossed to mHTT-ΔN17-exon1 to activate the transgene specifically in neurons, glia, muscle, and vascular cell lineages respectively. GFP fluorescence in living embryos demonstrates the spatially restricted expression of each line at 5 days post fertilization. e A disease free survival curve demonstrating that only elavl3:cre/mHTT-ΔN17-exon1 fish develop a behavioral phenotype similar to ubiquitous activation of mHTT-ΔN17-exon1, p < 0.01, Kaplan Meier survival analysis. f Disease progression of elavl3:cre/mHTT-ΔN17-exon1 fish is similar to ubiquitious mHTT-ΔN17-exon1 fish although temporally delayed, note the discontinuous x-axis (n = 23). Behavioral Stages are described in Fig. 2.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Neurodegener.