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Fig. 1
The med12/kgt mutant lacks the parapineal organ. (A-B′) Compared to WT (white arrow in A; dotted circle in B), med12 mutants showed no parapineal formation at 2 or 3 dpf (A′, B′) as revealed by the Tg[foxd3:GFP] transgene (used in all images to label the pineal complex unless indicated otherwise). (C-E′) Expression of parapineal markers in med12 mutants compared to WT embryos revealed by WISH (otx5 and gfi1.2 at 4 dpf; sox1a at 32 hpf). No parapineal markers were expressed in med12 mutants (C′, D′, E′), in contrast to WT embryos (C, D, E; black arrows).
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Reprinted from Developmental Biology, 385(1), Wu, S.Y., de Borsetti, N.H., Bain, E.J., Bulow, C.R., and Gamse, J.T., Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development, 13-22, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.