Gene
gfi1ab
- ID
- ZDB-GENE-040116-8
- Name
- growth factor independent 1A transcription repressor b
- Symbol
- gfi1ab Nomenclature History
- Previous Names
-
- gfi1.2
- gfi1
- gfi1b
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity and DNA-binding transcription factor activity. Involved in peripheral nervous system development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia. Is expressed in anterior lateral mesoderm; nervous system; and ventral wall of dorsal aorta. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Yu et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| severe congenital neutropenia 2 | Alliance | Neutropenia, severe congenital 2, autosomal dominant | 613107 |
| ?Neutropenia, nonimmune chronic idiopathic, of adults | 607847 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
|
UniProtKB:Q7SZV1
|
396 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gfi1ab-201
(1)
|
Ensembl | 1,228 nt |
Interactions and Pathways
No data available
Plasmids
No data available