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Fig. 7
Endothelial overexpression of id4 in id4 mutants can partially rescue their valve phenotype. Although id4-/- (A) generally lack spp1 expression, a subset does exhibit spp1 expression after endothelial specific id4 overexpression (B). Similarly, as compared to id4-/- which show ectopic bmp4 expression (C), id4 mutants with endothelial specific id4 overexpression (D) show reduced misexpression of bmp4. (E) Most of the larvae with endocardial re-expression of id4 in the id4-/- background show mild retrograde blood flow as compared to id4-/- siblings, most of which show high backflow. Scale bars, 100 µm.
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Reprinted from Developmental Biology, 412(1), Ahuja, S., Dogra, D., Stainier, D.Y., Reischauer, S., Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development, 71-82, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.