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Fig. 6
Id4 mediates Bmp signaling leading to spp1 expression. Increased expression of id4 (A, B) and spp1 (C, D) was observed at 52 hpf in Tg(hsp70l:bmp2b) embryos after heat shock at 26 and 48 hpf for 30 min at 37 ºC. (E, F) spp1 expression was examined in id4 wild-type siblings and mutants in the Tg(hsp70l:bmp2b) background at 52 hpf after previously mentioned heat shock conditions. Unlike their id4+/+ siblings (E), most of the id4-/- (F) did not show an increase in spp1 expression after heat shock induced bmp2b overexpression. Scale bars, 100 µm.
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Reprinted from Developmental Biology, 412(1), Ahuja, S., Dogra, D., Stainier, D.Y., Reischauer, S., Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development, 71-82, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.