ZFIN Image: Cheng et al., 2015, Fig. 7

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Fig. 7

The inhibition of RA biosynthesis by DEAB induces distal fates but fails to rescue CS formation in sim1a morphants. DMSO control or 1.67×10⁵ M DEAB treatments of (A) wild-types or (B) sim1a morphant embryos from 75% epi to the 5–7 ss were performed. WISH analysis in embryos at 24 hpf for distal segment markers (slc12a1, stc1, and slc12a3) (purple) and the somites (smyhc1) (red). Black bars represent segment domains in correlation to somite numbers. Embryo anterior is located to the left. Insets show dorsal view of the CS. Abbreviations: CS – corpuscles of Stannius; DE – distal early; DEAB – 4-diethylaminobenzaldehyde; DL – distal late; epi – epiboly; hpf – hours post fertilization; ss – somite stage; WISH – whole mount in situ hybridization.

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Acknowledgments

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Reprinted from Developmental Biology, 399(1), Cheng, C.N., Wingert, R.A., Nephron proximal tubule patterning and corpuscles of Stannius formation are regulated by the sim1a transcription factor and retinoic acid in zebrafish, 100-16, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.