Gene
stc1
- ID
- ZDB-GENE-060825-79
- Name
- stanniocalcin 1
- Symbol
- stc1 Nomenclature History
- Previous Names
-
- zgc:153307
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Predicted to be involved in intracellular calcium ion homeostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in corpuscles of Stannius and pronephric distal early tubule. Orthologous to human STC1 (stanniocalcin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14379 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-stc1 | N/A | Kawabata et al., 2015 |
| MO2-stc1 | N/A | Guan et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR004978 | Stanniocalcin |
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Domain Details Per Protein
| Protein | Length | Stanniocalcin |
|---|---|---|
|
UniProtKB:Q0P481
|
250 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-67O1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153307 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192533 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045457 (1) | 979 nt | ||
| Genomic | GenBank:BX004845 (1) | 165089 nt | ||
| Polypeptide | UniProtKB:Q0P481 (1) | 250 aa |
- Li, S., Liu, C., Goldstein, A., Xin, Y., Ke, C., Duan, C. (2021) Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a. Frontiers in cell and developmental biology. 9:662915
- Chambers, B.E., Clark, E.G., Gatz, A.E., Wingert, R.A. (2020) Kctd15 regulates nephron segment development by repressing Tfap2a activity. Development (Cambridge, England). 147(23):
- Chambers, B.E., Gerlach, G.F., Clark, E.G., Chen, K.H., Levesque, A.E., Leshchiner, I., Goessling, W., Wingert, R.A. (2019) Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Development (Cambridge, England). 146(13):
- Barrodia, P., Patra, C., Swain, R.K. (2018) EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish. Cell & Bioscience. 8:53
- Morales, E.E., Handa, N., Drummond, B.E., Chambers, J.M., Marra, A.N., Addiego, A., Wingert, R.A. (2018) Homeogene emx1 is required for nephron distal segment development in zebrafish. Scientific Reports. 8:18038
- Naylor, R.W., Chang, H.G., Qubisi, S., Davidson, A.J. (2018) A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion. eLIFE. 7:
- Drummond, B.E., Li, Y., Marra, A.N., Cheng, C.N., Wingert, R.A. (2017) The tbx2a/b transcription factors direct pronephros segmentation and corpuscle of Stannius formation in zebrafish. Developmental Biology. 421(1):52-66
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Shu, Y., Lou, Q., Dai, Z., Dai, X., He, J., Hu, W., Yin, Z. (2016) The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models. Scientific Reports. 6:18597
- Cheng, C.N., Wingert, R.A. (2015) Nephron proximal tubule patterning and corpuscles of Stannius formation are regulated by the sim1a transcription factor and retinoic acid in zebrafish. Developmental Biology. 399(1):100-16
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