ZFIN Image: Li et al., 2014, Fig. 3

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Fig. 3

mecom knockdown leads to an expanded PST segment. (A) At 24 hpf, WISH indicates proximal segments marked by slc4a4a elaborated in mecom morphants. Within proximal domains, PCT labeled by slc20a1a was not affected compared with wild type embryos. Knockdown of mecom induced a 3-somite expansion in trpm7-expressing PST in morphant pronephros at 24 hpf, which could be rescued by co-injecting mecom cRNA along with mecom morpholinos. (B) Schematic summary of proximal segment organization in wild type, mecom morphant, and mecom rescued embryos, with PST alterations highlighted in yellow. Abbreviations: PCT (proximal convoluted tubule), and PST (proximal straight tubule).

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Acknowledgments

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Reprinted from Developmental Biology, 386(1), Li, Y., Cheng, C.N., Verdun, V.A., and Wingert, R.A., Zebrafish nephrogenesis is regulated by interactions between retinoic acid, mecom, and Notch signaling, 111-122, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.