Gene

slc4a4a

ID
ZDB-GENE-060526-274
Name
solute carrier family 4 member 4a
Symbol
slc4a4a Nomenclature History
Previous Names
  • slc4a4
  • id:ibd2520
  • NBC1 (1)
  • NBCe1 (1)
  • si:dkey-256m11.1
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Enables sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Predicted to act upstream of or within anion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including central nervous system; eye; intermediate mesoderm; optic cup; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
23 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Sussman et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc4a4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Renal tubular acidosis, proximal, with ocular abnormalities 604278
Associated With slc4a4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011531 Bicarbonate transporter, C-terminal
Domain IPR013769 Band 3 cytoplasmic domain
Family IPR003020 Bicarbonate transporter, eukaryotic
Family IPR003024 Sodium bicarbonate cotransporter
Homologous_superfamily IPR016152 Phosphotransferase/anion transporter
Domain Details Per Protein
Protein Length Band 3 cytoplasmic domain Bicarbonate transporter, C-terminal Bicarbonate transporter, eukaryotic Phosphotransferase/anion transporter Sodium bicarbonate cotransporter
UniProtKB:A0A2R8PYB9 1114
UniProtKB:A0A2R8QD45 1073
UniProtKB:F1QPJ5 444
UniProtKB:B3DGX8 1073
UniProtKB:F1QHT2 1082
UniProtKB:Q3ZMH2 1082
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations