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Fig. 9 Symmetry breaking in MZjek is abnormal downstream of flow establishment. (A,B) charon expression at KV in wildtype (A) and MZjek (B) embryos at 14 SS with corresponding ratios of left:right side expression quantification. (C) Ratio of left sided:right sided expression of charon surrounding KV in wildtype and MZjek (**p<0.01). (D,E) Confocal immunofluorescence of KV using anti-acetylated alpha-tubulin (green) and anti-phosphorylated CaMK-II (red) to visualize activated CaMK-II in cells surrounding the KV in wildtype (D) and MZjek (E) embryos at 12 SS (N=26, ***p<0.001).
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Reprinted from Developmental Biology, 387(2), Superina, S., Borovina, A., and Ciruna, B., Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry, 154-166, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.