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Zhang et al., 2014 - Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish

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Fig. 2 Expression of bach1b, nrf2a and mafK in the exocrine pancreas as shown by using double in situ hybridization. The fluorescein-labeled probe indicated the expression areas (red) of try, an exocrine pancreas marker (A,B,C). Digoxigenin-labeled probes indicated the expression areas (blue) of bach1b (D,E,F), nrf2a (G,H,I) and mafK (J,K,L). The colocalization of try with bach1b (M,N,O), nrf2a (P,Q,R), or mafK (S,T,U) in the exocrine pancreas was shown by using double in situ hybridization. Longitudinal sections are shown in A,D,G,J,M,P,S; sagittal sections are shown in B,E,H,K,N,Q,T; and cross-sections are shown in C,F,I,L,O,R,U. All larvae examined were at 84 hpf. Arrows indicate the exocrine pancreas.

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