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Fig. 8
wnt8a.2 over-expression causes a posterior mesoderm defect. Posterior views of tbx6l expression in posterior mesoderm. White arrows indicate equivalent positions in each embryo, corresponding to position of tailbud. Arrowheads point to posterior limit of notochord. Treatment indicated in lower right. (A) Control MO embryo resembles wnt8a.2 MO injected embryo. (B) UTR2 TP MO causes gaps to form (white arrow) in the tbx6l domain near the notochord. (C) Gaps are absent or nearly absent (white arrow) in co-injected embryos.
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Reprinted from Developmental Biology, 386(1), Wylie, A.D., Fleming, J.A., Whitener, A.E., and Lekven, A.C., Post-transcriptional regulation of wnt8a is essential to zebrafish axis development, 53-63, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.