Gene
tbx16l
- ID
- ZDB-GENE-980526-171
- Name
- T-box transcription factor 16, like
- Symbol
- tbx16l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in paraxial mesoderm formation and somite development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Is expressed in embryonic structure; hematopoietic system; mesoderm; and post-vent region. Orthologous to human TBX6 (T-box transcription factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 73 figures from 53 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb123 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Morrow et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 5 | Alliance | Spondylocostal dysostosis 5 | 122600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:P79742
|
473 | |||||
|
UniProtKB:A0A8M6Z0I2
|
376 | |||||
|
UniProtKB:A0A8M6YZ11
|
492 | |||||
|
UniProtKB:A0A8M1PB76
|
473 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tbx16l-201
(1)
|
Ensembl | 3,080 nt |
Interactions and Pathways
No data available
Plasmids
No data available