Gene
tbx16l
- ID
- ZDB-GENE-980526-171
- Name
- T-box transcription factor 16, like
- Symbol
- tbx16l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within paraxial mesoderm formation and somite development. Predicted to be located in nucleus. Is expressed in embryonic structure; hematopoietic system; mesoderm; and post-vent region. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 5. Orthologous to human TBX6 (T-box transcription factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 73 figures from 53 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb123 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Morrow et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 5 | Alliance | Spondylocostal dysostosis 5 | 122600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:P79742
|
473 | |||||
|
UniProtKB:A0A8M6Z0I2
|
376 | |||||
|
UniProtKB:A0A8M6YZ11
|
492 | |||||
|
UniProtKB:A0A8M1PB76
|
473 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tbx16l-201
(1)
|
Ensembl | 3,080 nt |
Interactions and Pathways
No data available
Plasmids
No data available