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Zuniga et al., 2011 - Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton

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Fig. 6 Edn1 and Jag1b negatively regulate grem2 expression. (A-F) Confocal sections of in situ hybridization for grem2 (red) and dlx2a (green) in controls (A, n=62), jag1b^b1105 mutant (B, n=9), edn1^-/- mutant (C, n=5), UAS:Edn1 (D, n=17), hsp70I:dnBmpr1a-GFP (E, n=32) and UAS:Bmp4 (F, n=23) embryos at 36 hpf. In UAS:Edn1 embryos, grem2 expression was seen throughout the mandibular and hyoid arches, except for the ventral-most domain (white arrow). In hsp70I:dnBmpr1a-GFP embryos, grem2 expression shifted to ventral regions (yellow arrow) and was reduced dorsally (white arrowhead). Dorsal (D), intermediate (I) and ventral (V) domains of the mandibular (1) and hyoid (2) arches are labeled. Scale bar: 50 μm. (G,H) BRE:GFP expression increased throughout the dorsal and intermediate arch domains of edn1^-/- mutants (n=4) compared with wild-type siblings (n=16).

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