Gene

grem2b

ID
ZDB-GENE-030911-9
Name
gremlin 2, DAN family BMP antagonist b
Symbol
grem2b Nomenclature History
Previous Names
  • grem2
  • prdc (1)
  • zgc:112207
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have BMP binding activity and receptor ligand activity. Involved in BMP signaling pathway involved in heart development; cardiac atrium development; and cartilage morphogenesis. Predicted to localize to extracellular space. Is expressed in several structures, including digestive system; head; optic cup; optic vesicle; and swim bladder bud. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grem2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Tooth agenesis, selective, 9 617275
Associated With grem2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004133 DAN
Domain IPR006207 Cystine knot, C-terminal
Family IPR017159 Gremlin-1/2
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine knot, C-terminal Cystine-knot cytokine DAN Gremlin-1/2
UniProtKB:Q566Z5 166
UniProtKB:A0A0B5JK45 166
UniProtKB:A0A0R4ICD7 166
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations