Fig. 6 Persistent Nr2e3 expression in lor. (A–D) Transverse cryosections from 2- (A), 3- (B), and 4-dpf (C and D) WT and tbx2bp25bbtl embryos immunolabeled for rods (4C12, green) and Nr2e3 (red), and counterstained with DAPI (blue); dorsal is up. (A) At 2 dpf, labeling for Nr2e3 is observed in the inner and outer retina before differentiation of photoreceptors. (B) At 3 dpf, Nr2e3 labeling is restricted to developing photoreceptors in the ONL. In the ventral retina, Nr2e3 nuclear labeling colocalizes with immunolabeling for rods (inset). (C and D) At 4 dpf, expression of Nr2e3 persists in differentiating rods in WT and tbx2bp25bbtl retinas.
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