ZFIN Image: Hatler et al., 2009, Fig. 1

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Figure Caption

Fig. 1 Cx43.4 is specifically required for L–R patterning. Dorsal views of 30 hpf embryos processed for in situ hybridization with a cardiac myosin light chain probe show normal looping of the heart tube towards the right in controls (A) and aberrant looping to the left in Cx43.4 morphants (B). (C) Quantification of heart looping in four independent knockdown experiments is represented as means ± SEM. The dotted line in all graphs shows the theoretical maximum value for randomization. (D) Ventral view of autofluorescence in the gut of a 5 dpf larva, specifically the gall bladder (arrowhead) and pancreas (arrow); compare with (E) the Cx43.4 morphant where these organs are reversed.

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Acknowledgments

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Reprinted from Developmental Biology, 336(2), Hatler, J.M., Essner, J.J., and Johnson, R.G., A gap junction connexin is required in the vertebrate left-right organizer, 183-191, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.