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Fig. 3 Tbx5 heart defects can be rescued by CaMK-II. Wild type or cmlc2:DsRed transgenic embryos (k–o) were injected with the mismatch MO (5 ng), camk2b2 MO (2 ng) or tbx5 MO (5 ng) with or without 40 pg wild type δC CaMK-II cDNA and imaged at 72 hpf (a–e; k–y) or subjected to cmlc2 in situ hybridization at 48 hpf (f–j). Scale bar = 0.5 mm and anterior is to the left. In f and k, a = atrium and v = ventricle. In p–t, insets reveal bmp4 in situ hybridization patterns in the pectoral fin area. In u–y, brackets indicate extent of pectoral fin length.
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Reprinted from Developmental Biology, 330(1), Rothschild, S.C., Easley, C.A. 4th, Francescatto, L., Lister, J.A., Garrity, D.M., and Tombes, R.M., Tbx5-mediated expression of Ca(2+)/calmodulin-dependent protein kinase II is necessary for zebrafish cardiac and pectoral fin morphogenesis, 175-184, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.