ZFIN Image: Ke et al., 2008, Fig. 6

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Figure Caption

Fig. 6 Gli2b and r4. nkx2.2 expression in the hindbrain in 30 hpf, dorsal view. (A) control, (B) Gli2b morphant. nkx2.2 expression domain was slightly expanded in Gli2b morphant (two-headed arrow). (C) yot^-/- mutant. (D) yot^-/-/Gli2b morphant without nkx2.2 expression in the hindbrain (black arrow). This phenotype is similar to that in smu^-/- (E). (F) Dorsal and (H) lateral view of netrin1a expression in the hindbrain of 30 hpf controls and Gli2b morphants (G, I). In Gli2b morphants netrin1a expression in the ventral hindbrain domain was up-regulated and expanded laterally. (J) In yot^-/-, netrin1a expression was affected ventrally, but unaffected dorsally. After injection of Gli2b MO into yot^-/- only a trace of expression was detected in the r4 (black arrow, F). Black arrowhead in panel H—floor plate expression domain; white bullet line in panels H and J defines D-V extent of expression domain. Abbreviations: e, ear.

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Acknowledgments

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Reprinted from Molecular and cellular neurosciences, 37(2), Ke, Z., Kondrichin, I., Gong, Z., and Korzh, V., Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment, 388-401, Copyright (2008) with permission from Elsevier. Full text @ Mol. Cell Neurosci.