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Fig. 8 Mitotic activity in the retinas of control and γ-secretase-inhibited (CE) embryos. (A–D) Retinal cryosections labeled with phosphorylated histone H3 (pH3) antibody (Cy3—red). (A) Control and (B) CE-treated retinas labeled with anti-pH3 at 48 hpf. Mitotic cells were present in the outer retina in control and drug-treated retinas. By 65 hpf, mitotic activity was restricted to the germinal zone at the ciliary margin (arrow) and outer nuclear layer (arrowheads) in control (C) and CE-treated (D). Scale bar = 50 μm (A–D).
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Reprinted from Developmental Biology, 278(2), Bernardos, R.L., Lentz, S.I., Wolfe, M.S., and Raymond, P.A., Notch-Delta signaling is required for spatial patterning and Muller glia differentiation in the zebrafish retina, 381-395, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.