IMAGE

Fig. 1

ID
ZDB-IMAGE-071001-118
Genes
Source
Figures for Zecchin et al., 2007
Image
Figure Caption

Fig. 1  Inhibition of Notch signalling increases differentiation of beta-cells. In situ hybridizations showing insulin (A–D) somatostatin (PPSS2) (E–H) and glucagon (I–L) expression in mib mutants and DAPT-treated embryos. The pancreatic area is depicted. Insulin and somatostatin expression, in blue, is increased in mib mutants and DAPT-treated embryos (C, D, G, H) compared with controls (A, B, E, F). Conversely, glucagon expression is reduced or absent (compare K, L with I, J). Embryos in panels A, E, I and B, F, J should be compared with embryos in panels C, G, K and D, H, L, respectively. Embryos have been hybridized at 72 hpf and are presented in a ventral view with anterior to the left. Scale bar in panel A is 50 μm.

Figure Data
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 301(1), Zecchin, E., Filippi, A., Biemar, F., Tiso, N., Pauls, S., Ellertsdottir, E., Gnugge, L., Bortolussi, M., Driever, W., and Argenton, F., Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish, 192-204, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.