ZFIN Image: Shi et al., 2006, Fig. 8

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Figure Caption

Fig. 8 Cell proliferation in the foxe3 morphant lens. Frozen sections from control and foxe3 morpholino-injected embryos were immunolabeled for PCNA, a marker for proliferating cells. The control lens exhibits very few PCNA-positive cells at 5 and 7 dpf (panels A and C, respectively; arrows). Large numbers of anti-PCNA-labeled cells are identified in the foxe3 morphant lens at these ages (panels B and D, arrows). Small groups of PCNA-expressing cells are identified in the retinal circumferential marginal zones of both control and morphant eyes (panels A–D, arrowheads). A region of PCNA-labeled cells extends from the iris across the lens in the 7 dpf foxe3 morphant (panel D, double arrow). In addition, a region of cell proliferation in the brain is identified in the 5 dpf foxe3 morphant section (panel B, asterisk). Scale bars = 50 μm. Abbreviations: PL, photoreceptor layer; INL, inner nuclear layer and GCL, ganglion cell layer.

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Acknowledgments

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Reprinted from Mechanisms of Development, 123(10), Shi, X., Luo, Y., Howley, S., Dzialo, A., Foley, S., Hyde, D.R., and Vihtelic, T.S., Zebrafish foxe3: Roles in ocular lens morphogenesis through interaction with pitx3, 761-782, Copyright (2006) with permission from Elsevier. Full text @ Mech. Dev.