Fig. 2

Fig. 2 pCREB immunoreactivity in adult zebrafish brain is localized to cells of all known proliferative regions (sagittal (A) and coronal (B) sections). The sixteen known proliferation zones [PZ] in adult zebrafish brain are located within (rostral to caudal): [1] olfactory bulb, [2] ventral telencephalon, [3] dorsal telencephalon, [4] pre-optic area, [5] ventral thalamus, [6] habenula, [7] periventricular pretectal area, [8] dorsal thalamus, [9] posterior tuberculum, [10] hypothalamus, [11] optic tectum, [12] dorsal torus longitudinalis, [13] posterior mesencephalic lamina, [14a] molecular layer of cerebellum, [14b] cerebellar caudal lobe and [15] vagal lobe. An additional proliferation zone exists within the medulla oblongata, extending caudally into the spinal cord (not shown). Additional isolated pCREB+ cells are found in the optic tract (OT), and clusters of pCREB+ cells are present in the corpus cerebelli (CC), granular zone of cerebellum (C), crista cerebellaris (CCe), corpus mammilare (CM), commisura ansulata and oculomotor nerve (CA) and diffuse nucleus of the inferior lobe (IL; A), as well as in the periventricular grey zone (PGZ) and throughout the torus longitudinalis (TL) proper (B). Scale bar 200 µm; OB, olfactory bulb; T, telencephalon; M, mesencephalon; OT, optic tract; D, diencephalon; R, rhombencephalon; C, cerebellum; Me, medulla; TeO, optic tectum; CT, commisura tecti; PPv, ventral periventricular pretectal nucleus; CP, central posterior thalamic nuclei; TPp, periventricular nucleus of posterior tuberculum; PTN, posterior tuberal nucleus.