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Fig. 7 Irx1a expression is depended on Fgf signaling but not shh signaling. Lateral view of 48 hpf (A,B,E,F) and 36 hpf (C,D,G,H) retinas. Shh signaling inhibitor cyclopamine treated (24–48 hpf) embryos (A,E) showed comparable ath5 and irx1a expression as the mock solution treated controls (B,F). In contrast, both ath5 and irx1a expression were almost absent in Fgf signaling inhibitor SU5402 treated (23–36 hpf) embryos (C,G) in compare to the control (D, H). Asterisks (*) indicate the position of the choroid fissure.
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Reprinted from Mechanisms of Development, 123(3), Cheng, C.W., Yan, C.H., Hui, C.C., Strähle, U., and Cheng, S.H., The homeobox gene irx1a is required for the propagation of the neurogenic waves in the zebrafish retina, 252-263, Copyright (2006) with permission from Elsevier. Full text @ Mech. Dev.