Fig. 5

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Fig. 5 Pax8 mediates the early Fgf-dependent induction of pax2a expression. In fgf8– mutant embryos at the five-somite stage, the preotic pax2a expression is reduced in size (B) compared with wildtype embryos of the same age (A). fgf8– mutant embryos after Pax8 depletion show an even further reduction of preotic pax2a expression (C). The defects in Pax2a expression are later manifested in a slightly reduced ear in fgf8– mutant embryos (E) or more severely reduced ear in fgf8– embryos depleted of Pax8 (F) in comparison with wildtype embryos at 50 h (D). (A-C) Dorsal views, anterior towards the top; (D-F) side views, anterior towards the left, dorsal towards the top. Scale bar: 120 μm for A-C; 180 μm for D-F.