Gene

dnmt3bb.2

ID
ZDB-GENE-990712-11
Name
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
Symbol
dnmt3bb.2 Nomenclature History
Previous Names
  • dnmt3-1 (1)
  • dnmt3
  • dnmt3b3 (1)
  • Zmt3 (1)
  • etID41458.23 (1)
  • wu:fa11d06 (1)
  • wu:fb73b09 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable DNA (cytosine-5-)-methyltransferase activity; DNA binding activity; and metal ion binding activity. Acts upstream of or within several processes, including exocrine pancreas development; eye morphogenesis; and pharyngeal system development. Predicted to be located in nucleus. Is expressed in several structures, including brain; digestive system; eye; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune disease (multiple); carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnmt3bb.2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency-centromeric instability-facial anomalies syndrome 1 Alliance Immunodeficiency-centromeric instability-facial anomalies syndrome 1 242860
Facioscapulohumeral muscular dystrophy 4, digenic 619478
Associated With dnmt3bb.2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018117 DNA methylase, C-5 cytosine-specific, active site
Domain IPR000313 PWWP domain
Domain IPR001715 Calponin homology domain
Domain IPR025766 ADD domain
Domain IPR040552 DNMT3, cysteine rich ADD domain
Family IPR001525 C-5 cytosine methyltransferase
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Homologous_superfamily IPR036872 CH domain superfamily
Domain Details Per Protein
Protein Length ADD domain C-5 cytosine methyltransferase Calponin homology domain CH domain superfamily DNA methylase, C-5 cytosine-specific, active site DNMT3, cysteine rich ADD domain PWWP domain S-adenosyl-L-methionine-dependent methyltransferase
UniProtKB:A3QJV0 1448
UniProtKB:Q588C7 1448
UniProtKB:Q9W6K7 842
UniProtKB:A0A2R8RVC1 1447
UniProtKB:B3DGP2 1448
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations