ZFIN ID: ZDB-GENE-990603-12
Gene Name: wnt 11, family member 2
Gene Symbol: wnt11f2    Nomenclature History

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Previous Names: wnt11 (1), cb748 (1), silberblick, slb

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in several processes, including Kupffer's vesicle development; embryonic morphogenesis; and establishment of mitotic spindle orientation. Localizes to the plasma membrane. Is expressed in several structures, including EVL; head; mesoderm; musculature system; and tail bud. Orthologous to human WNT11 (Wnt family member 11).
Genome Resources: Alliance (1),  Gene:791595 (1),  Ensembl(GRCz11):ENSDARG00000004256 (1)
Note: From Postlethwait et al. (2019) "analysis of phylogenies and conserved syntenies from sequenced genomes clarifies the evolutionary history and nomenclature of the Wnt11 gene family to better connect teleost models of human disease to human biology."
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
tx226 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tz216 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • u148 Unknown Unknown Unknown
    wnt11f2_unspecified Unspecified Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-wnt11f2 N/A 22
    MO2-wnt11f2 N/A 9
    MO3-wnt11f2 N/A 1
    DISEASE ASSOCIATED WITH wnt11f2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH wnt11f2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-cell adhesion (more)
    Cellular Component plasma membrane (more)
    Molecular Function protein heterodimerization activity (more)
    GO Terms (all 50)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR005817 Wnt
    Conserved_site IPR018161 Wnt protein, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA wnt11-201 (1)    Ensembl 2132
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-wnt11 polyclonal Rabbit IHC AnaSpec
    2
    CONSTRUCTS WITH SEQUENCES FROM wnt11f2 No data available
    MARKER RELATIONSHIPS
    wnt11f2 Contained in: [BAC] CH73-223D24 (1)
    wnt11f2 Contains: [SNP] rs3727880 (1)
    wnt11f2 Encodes: [EST] cb748 (1), eu266 (1)
    [cDNA] MGC:193977 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001144804 (1)
    Genomic GenBank:CU571324 (1) 78830 bp
    Select Tool
    Polypeptide UniProtKB:O73864 (1) 354 aa
    Sequence Information (all 21)
    ORTHOLOGY for wnt11f2 ( Chr: 5 )
    CITATIONS (177)