Gene
id1
- ID
- ZDB-GENE-990415-96
- Name
- inhibitor of DNA binding 1, HLH protein
- Symbol
- id1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable transcription corepressor activity. Acts upstream of or within negative regulation of neurogenesis and regulation of neuron differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; ectoderm; germ ring; mesoderm; and pleuroperitoneal region. Orthologous to human ID1 (inhibitor of DNA binding 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb108 (24 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ka706 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-id1 | Zhang et al., 2021 | |
| CRISPR2-id1 | Zhang et al., 2021 | |
| CRISPR3-id1 | Zhang et al., 2021 | |
| MO1-id1 | N/A | (2) |
| MO2-id1 | N/A | Place et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA-binding protein inhibitor | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|
| UniProtKB:Q6IQW5 | InterPro | 128 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| antisense |
ottdart00000060060
(1)
|
Ensembl | 1,793 nt | ||
| mRNA |
id1-201
(1)
|
Ensembl | 1,006 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(id1:EGFP) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-219E24 | ZFIN Curated Data | |
| Contains | SNP | rs3728370 | Stickney et al., 2002 | |
| Contains | SNP | rs3728371 | Stickney et al., 2002 | |
| Contains | SNP | rs3728372 | Stickney et al., 2002 | |
| Encodes | EST | cb108 | Thisse et al., 2001 | |
| Encodes | EST | fb16a08 | Rauch et al., 2003 | |
| Encodes | EST | fb57e11 | ZFIN Curated Data | |
| Encodes | EST | ibd1174 | ||
| Encodes | cDNA | MGC:86569 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131245 (1) | 1010 nt | ||
| Genomic | GenBank:CU207354 (1) | 141089 nt | ||
| Polypeptide | UniProtKB:Q6IQW5 (1) | 128 aa |
- Fernezelian, D., Pfitsch, S., Rastegar, S., Diotel, N. (2024) Mapping the cellular expression patterns of vascular endothelial growth factor aa and bb genes and their receptors in the adult zebrafish brain during constitutive and regenerative neurogenesis. Neural Development. 19:1717
- Wang, Y.S., Chen, Y.T., Wu, C.Y. (2023) Functional characterization of stap2b in zebrafish vascular development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e23053e23053
- Tsaryk, R., Yucel, N., Leonard, E.V., Diaz, N., Bondareva, O., Odenthal-Schnittler, M., Arany, Z., Vaquerizas, J.M., Schnittler, H., Siekmann, A.F. (2022) Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Scientific Reports. 12:4795
- Yang, S., Ning, G., Hou, Y., Cao, Y., Xu, J., Wu, J., Zhang, T., Wang, Q. (2022) Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding. iScience. 25:104495
- Kikel-Coury, N.L., Brandt, J.P., Correia, I.A., O'Dea, M.R., DeSantis, D.F., Sterling, F., Vaughan, K., Ozcebe, G., Zorlutuna, P., Smith, C.J. (2021) Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function. PLoS Biology. 19:e3001444
- Ma, J., Huang, Y., Jiang, P., Liu, Z., Luo, Q., Zhong, K., Yuan, W., Meng, Y., Lu, H. (2021) Pyridaben induced cardiotoxicity during the looping stages of zebrafish (Danio rerio) embryos. Aquatic toxicology (Amsterdam, Netherlands). 237:105870
- Meng, Y., Zhong, K., Chen, S., Huang, Y., Wei, Y., Wu, J., Liu, J., Xu, Z., Guo, J., Liu, F., Lu, H. (2021) Cardiac toxicity assessment of pendimethalin in zebrafish embryos. Ecotoxicology and environmental safety. 222:112514
- Sun, Y., Yang, F., Liu, Y., Yu, M., Wu, F., Wang, G. (2021) Di-2-ethylhexyl phthalate induces heart looping disorders during zebrafish development. Toxicology and industrial health. 37(7):391-397
- Zhang, G., Lübke, L., Chen, F., Beil, T., Takamiya, M., Diotel, N., Strähle, U., Rastegar, S. (2021) Neuron-Radial Glial Cell Communication via BMP/Id1 Signaling Is Key to Long-Term Maintenance of the Regenerative Capacity of the Adult Zebrafish Telencephalon. Cells. 10(10):
- Cang, Z., Nie, Q. (2020) Inferring spatial and signaling relationships between cells from single cell transcriptomic data. Nature communications. 11:2084
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