Gene
hsp90ab1
- ID
- ZDB-GENE-990415-95
- Name
- heat shock protein 90, alpha (cytosolic), class B member 1
- Symbol
- hsp90ab1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and receptor ligand inhibitor activity. Acts upstream of or within blood vessel development and leukocyte migration. Predicted to be located in dynein axonemal particle; extracellular region; and nucleus. Predicted to be part of aryl hydrocarbon receptor complex. Predicted to be active in cytosol; perinuclear region of cytoplasm; and plasma membrane. Is expressed in eye and head. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77433 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019805 | Heat shock protein Hsp90, conserved site |
| Domain | IPR003594 | Histidine kinase/HSP90-like ATPase domain |
| Domain | IPR020575 | Heat shock protein Hsp90, N-terminal |
| Family | IPR001404 | Heat shock protein Hsp90 family |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
| Homologous_superfamily | IPR037196 | HSP90, C-terminal domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | Heat shock protein Hsp90, conserved site | Heat shock protein Hsp90 family | Heat shock protein Hsp90, N-terminal | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | HSP90, C-terminal domain | Ribosomal protein uS5 domain 2-type superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:O57521 | InterPro | 725 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsp90ab1-201
(1)
|
Ensembl | 3,386 nt | ||
| mRNA |
hsp90ab1-204
(1)
|
Ensembl | 4,561 nt | ||
| ncRNA |
hsp90ab1-002
(1)
|
Ensembl | 641 nt | ||
| ncRNA |
hsp90ab1-003
(1)
|
Ensembl | 511 nt |
Interactions and Pathways
No data available
Plasmids
No data available