Gene

hsp90ab1

ID
ZDB-GENE-990415-95
Name
heat shock protein 90, alpha (cytosolic), class B member 1
Symbol
hsp90ab1 Nomenclature History
Previous Names
  • hsp90b (2)
  • hsp90beta
  • wu:fa29f01
  • wu:fa91e11 (1)
  • wu:fd59e11
  • wu:gcd22h07
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have several functions, including ATP binding activity; disordered domain specific binding activity; and unfolded protein binding activity. Involved in blood vessel development and leukocyte migration. Predicted to localize to several cellular components, including aryl hydrocarbon receptor complex; cytosol; and perinuclear region of cytoplasm. Is expressed in eye and head. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hsp90ab1 Human Ortholog
No data available
Associated With hsp90ab1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019805 Heat shock protein Hsp90, conserved site
Domain IPR003594 Histidine kinase/HSP90-like ATPase
Domain IPR020575 Heat shock protein Hsp90, N-terminal
Family IPR001404 Heat shock protein Hsp90 family
Homologous_superfamily IPR020568 Ribosomal protein S5 domain 2-type fold
Homologous_superfamily IPR036890 Histidine kinase/HSP90-like ATPase superfamily
Homologous_superfamily IPR037196 HSP90, C-terminal domain
Domain Details Per Protein
Protein Length Heat shock protein Hsp90, conserved site Heat shock protein Hsp90 family Heat shock protein Hsp90, N-terminal Histidine kinase/HSP90-like ATPase Histidine kinase/HSP90-like ATPase superfamily HSP90, C-terminal domain Ribosomal protein S5 domain 2-type fold
UniProtKB:O57521 725
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations