Gene

hsp90ab1

ID

ZDB-GENE-990415-95

Name

heat shock protein 90, alpha (cytosolic), class B member 1

Symbol

hsp90ab1 Nomenclature History

Previous Names

hsp90b (2)
hsp90beta
wu:fa29f01
wu:fa91e11 (1)
wu:fd59e11
wu:gcd22h07

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have several functions, including ATP binding activity; disordered domain specific binding activity; and unfolded protein binding activity. Involved in blood vessel development and leukocyte migration. Predicted to localize to several cellular components, including aryl hydrocarbon receptor complex; cell surface; and perinuclear region of cytoplasm. Is expressed in eye and head. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:77433 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hsp90ab1 Human Ortholog

No data available

Associated With hsp90ab1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019805	Heat shock protein Hsp90, conserved site
Domain	IPR003594	Histidine kinase/HSP90-like ATPase
Domain	IPR020575	Heat shock protein Hsp90, N-terminal
Family	IPR001404	Heat shock protein Hsp90 family
Homologous_superfamily	IPR020568	Ribosomal protein S5 domain 2-type fold
Homologous_superfamily	IPR036890	Histidine kinase/HSP90-like ATPase superfamily
Homologous_superfamily	IPR037196	HSP90, C-terminal domain

Domain Details Per Protein

Protein	Length	Heat shock protein Hsp90, conserved site	Heat shock protein Hsp90 family	Heat shock protein Hsp90, N-terminal	Histidine kinase/HSP90-like ATPase	Histidine kinase/HSP90-like ATPase superfamily	HSP90, C-terminal domain	Ribosomal protein S5 domain 2-type fold
UniProtKB:O57521 InterPro	725

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	hsp90ab1-201 (1) Ensembl	3386 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	hsp90ab1-002 (1) Ensembl	641 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	hsp90ab1-003 (1) Ensembl	511 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations