Community Action Needed: Please respond to the NIH RFI
Gene

hspa8

ID
ZDB-GENE-990415-92
Name
heat shock protein 8
Symbol
hspa8 Nomenclature History
Previous Names
  • heat shock cognate 71-kd protein
  • hsc70
  • wu:fb01g06 (1)
  • wu:fi48b06 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Acts upstream of or within several processes, including fin regeneration; positive regulation of receptor-mediated endocytosis; and protein localization to early endosome. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in several structures, including head; immature eye; nervous system; presumptive neural plate; and swim bladder. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
26 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hspa8 Human Ortholog
No data available
Associated With hspa8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018181 Heat shock protein 70, conserved site
Family IPR013126 Heat shock protein 70 family
Homologous_superfamily IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
Homologous_superfamily IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
Homologous_superfamily IPR043129 ATPase, nucleotide binding domain
Domain Details Per Protein
Protein Length ATPase, nucleotide binding domain Heat shock protein 70, conserved site Heat shock protein 70 family Heat shock protein 70kD, C-terminal domain superfamily Heat shock protein 70kD, peptide-binding domain superfamily
UniProtKB:A0A2R8Q860 654
UniProtKB:P79984 649
UniProtKB:Q6TEQ5 649
UniProtKB:Q90473 649
UniProtKB:A0A0R4IMF8 634
UniProtKB:Q7ZVJ1 649
UniProtKB:Q1LY27 127
UniProtKB:A0A2R8QEN9 658
UniProtKB:Q6NYR4 649
UniProtKB:Q1LY29 188
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations