Gene
esrra
- ID
- ZDB-GENE-990415-68
- Name
- estrogen-related receptor alpha
- Symbol
- esrra Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity. Acts upstream of or within DNA-templated transcription; cell migration involved in gastrulation; and regulation of cartilage development. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including brain; integument; mesoderm; muscle; and tail bud. Orthologous to human ESRRA (estrogen related receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- ay556395 (26 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010268Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la014040Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021927Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028333Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nv1315 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-esrra | N/A | (2) |
| MO2-esrra | N/A | (2) |
| MO3-esrra | N/A | Kim et al., 2015 |
| MO4-esrra | N/A | Kim et al., 2015 |
| MO5-esrra | N/A | Guh et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR024178 | Estrogen receptor/oestrogen-related receptor |
| Family | IPR027289 | Oestrogen-related receptor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Estrogen receptor/oestrogen-related receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Oestrogen-related receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6Q6F6 | InterPro | 436 | ||||||||
| UniProtKB:A0A8M2B8J1 | InterPro | 441 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198K5 | ZFIN Curated Data | |
| Encodes | EST | ay556395 | Bertrand et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212955 (1) | 1311 nt | ||
| Genomic | GenBank:BX465841 (2) | 190913 nt | ||
| Polypeptide | UniProtKB:A0A8M2B8J1 (1) | 441 aa |
- Kurchaba, N., Charette, J.M., LeMoine, C.M.R. (2022) Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle. American journal of physiology. Regulatory, integrative and comparative physiology. 323(3):R319-R330
- Li, X., Guo, R., Yang, S., Zhang, X., Yin, X., Teng, L., Zhang, S., Ji, G., Li, H. (2022) Cd248a and Cd248b in zebrafish participate in innate immune responses. Frontiers in immunology. 13:970626
- Kumar, N., Zhao, H.N., Awoyemi, O., Kolodziej, E.P., Crago, J. (2021) Toxicity Testing of Effluent-Dominated Stream Using Predictive Molecular-Level Toxicity Signatures Based on High-Resolution Mass Spectrometry: A Case Study of the Lubbock Canyon Lake System. Environmental science & technology. 55(5):3070-3080
- Pradhan, S.J., Reddy, P.C., Smutny, M., Sharma, A., Sako, K., Oak, M.S., Shah, R., Pal, M., Deshpande, O., Dsilva, G., Tang, Y., Mishra, R., Deshpande, G., Giraldez, A.J., Sonawane, M., Heisenberg, C.P., Galande, S. (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nature communications. 12:6094
- Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Collins, M.M., Ahlberg, G., Hansen, C.V., Guenther, S., Marín-Juez, R., Sokol, A.M., El-Sammak, H., Piesker, J., Hellsten, Y., Olesen, M.S., Stainier, D.Y.R., Lundegaard, P.R. (2019) Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model. Proceedings of the National Academy of Sciences of the United States of America. 116(48):24115-24121
- Northam, C., LeMoine, C.M.R. (2019) Metabolic regulation by the PGC-1α and PGC-1β coactivators in larval zebrafish (Danio rerio). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 234:60-67
- Zare Mirakabad, H., Farsi, M., Malekzadeh Shafaroudi, S., Bagheri, A., Iranshahi, M., Moshtaghi, N. (2019) Comparison the Effect of Ferutinin and 17β-Estradiol on Bone Mineralization of Developing Zebrafish (Danio rerio) Larvae. International Journal of Molecular Sciences. 20(6)
- Geronikolou, S.A., Pavlopoulou, A., Kanaka-Gantenbein, C., Chrousos, G. (2018) Inter-species functional interactome of nuclear steroid receptors (R1). Frontiers in bioscience (Elite edition). 10:208-228
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