Gene
ncam1a
- ID
- ZDB-GENE-990415-31
- Name
- neural cell adhesion molecule 1a
- Symbol
- ncam1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Acts upstream of or within posterior commissure morphogenesis. Predicted to be located in plasma membrane. Is expressed in several structures, including anterior neural keel; myotome; nervous system; optic vesicle; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d828 (14 images)
- eu303 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Langhauser et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014026Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021897Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1470 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17923 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23936 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37307 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 6 of 6
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ncam1a | Charlton-Perkins et al., 2019 | |
| CRISPR2-ncam1a | Charlton-Perkins et al., 2019 | |
| MO1-ncam1a | N/A | (2) |
| MO2-ncam1a | N/A | Langhauser et al., 2012 |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Family | IPR009138 | Neural cell adhesion |
| Family | IPR050958 | Cell Adhesion and Cytoskeletal Organization |
| Family | IPR051170 | Neural and epithelial cell adhesion domain-containing protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ncam1a-201
(1)
|
Ensembl | 2,921 nt | ||
| mRNA |
ncam1a-202
(1)
|
Ensembl | 878 nt | ||
| mRNA |
ncam1a-206
(1)
|
Ensembl | 2,810 nt | ||
| mRNA |
ncam1a-207
(1)
|
Ensembl | 2,840 nt | ||
| ncRNA |
ncam1a-002
(1)
|
Ensembl | 903 nt | ||
| ncRNA |
ncam1a-004
(1)
|
Ensembl | 665 nt | ||
| ncRNA |
ncam1a-005
(1)
|
Ensembl | 528 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-112C20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-158E11 | ZFIN Curated Data | |
| Contained in | BAC | CH211-286C23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-65K19 | ZFIN Curated Data | |
| Encodes | EST | eu303 | Thisse et al., 2005 | |
| Encodes | EST | fj56g09 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d828 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:194084 | ZFIN Curated Data |
1 - 8 of 8
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131202 (1) | 2933 nt | ||
| Genomic | GenBank:BX005227 (2) | 187709 nt | ||
| Polypeptide | UniProtKB:A0A8M3ATS9 (1) | 1010 aa |
- Cao, Y., Xia, Y., Balowski, J.J., Ou, J., Song, L., Safi, A., Curtis, T., Crawford, G.E., Poss, K.D., Cao, J. (2022) Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration. Development (Cambridge, England). 149(4)
- Paudel, S., Gjorcheska, S., Bump, P., Barske, L. (2022) Patterning of cartilaginous condensations in the developing facial skeleton. Developmental Biology. 486:44-55
- Dries, R., Lange, A., Heiny, S., Berghaus, K.I., Bastmeyer, M., Bentrop, J. (2021) Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions. Frontiers in cell and developmental biology. 8:591011
- Pollock, N.M., Leighton, P., Neil, G., Allison, W.T. (2021) Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein. Prion. 15:70-81
- Wang, D., Wang, X., Huang, H., Wang, H. (2021) Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity. Journal of hazardous materials. 413:125414
- Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Liu, J., Sun, L., Zhang, H., Shi, M., Dahlgren, R.A., Wang, X., Wang, H. (2018) Response mechanisms to joint exposure of triclosan and its chlorinated derivatives on zebrafish (Danio rerio) behavior. Chemosphere. 193:820-832
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
1 - 10 of 34
Show