Gene
wnt10a
- ID
- ZDB-GENE-990415-278
- Name
- wingless-type MMTV integration site family, member 10a
- Symbol
- wnt10a Nomenclature History
- Previous Names
-
- etID309718.9 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within odontogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in caudal fin and nervous system. Human ortholog(s) of this gene implicated in Schopf-Schulz-Passarge syndrome; ectodermal dysplasia; and tooth agenesis. Orthologous to human WNT10A (Wnt family member 10A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Yuan et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb849 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| ihb850 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| sa12206 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31702 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41363 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41364 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-wnt10a | (2) | |
| CRISPR2-wnt10a | (2) | |
| CRISPR3-wnt10a | Zebrafish Nomenclature Committee | |
| MO1-wnt10a | N/A | Yuan et al., 2017 |
| MO2-wnt10a | N/A | Yuan et al., 2017 |
| MO3-wnt10a | N/A | Benard et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Schopf-Schulz-Passarge syndrome | Alliance | Schopf-Schulz-Passarge syndrome | 224750 |
| tooth agenesis | Alliance | Tooth agenesis, selective, 4 | 150400 |
| Ectodermal dysplasia 16 (odontoonychodermal dysplasia) | 257980 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Wnt | Wnt-10 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:B0V1G8 | InterPro | 442 | ||||
| UniProtKB:P43446 | InterPro | 442 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
wnt10a-201
(1)
|
Ensembl | 1,608 nt | ||
| mRNA |
wnt10a-202
(1)
|
Ensembl | 1,051 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-wnt10a | polyclonal | Rabbit |
|
Aviva Systems Biology
|
2 |
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31M21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194456 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194458 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130980 (1) | 1608 nt | ||
| Genomic | GenBank:CR847976 (2) | 222676 nt | ||
| Polypeptide | UniProtKB:B0V1G8 (1) | 442 aa |
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Benard, E.L., Küçükaylak, I., Hatzold, J., Berendes, K.U.W., Carney, T.J., Beleggia, F., Hammerschmidt, M. (2023) wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(6):566-592
- Jackson, A., Lin, S.J., Jones, E.A., Chandler, K.E., Orr, D., Moss, C., Haider, Z., Ryan, G., Holden, S., Harrison, M., Burrows, N., Jones, W.D., Loveless, M., Petree, C., Stewart, H., Low, K., Donnelly, D., Lovell, S., Drosou, K., Genomics England Research Consortium, Solve-RD consortium, Varshney, G.K., Banka, S. (2023) Clinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14. HGG advances. 4:100186100186
- Cao, Z., Meng, Y., Gong, F., Xu, Z., Liu, F., Fang, M., Zou, L., Liao, X., Wang, X., Luo, L., Li, X., Lu, H. (2021) Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration. Proceedings of the National Academy of Sciences of the United States of America. 118(2):
- Square, T.A., Sundaram, S., Mackey, E.J., Miller, C.T. (2021) Distinct tooth regeneration systems deploy a conserved battery of genes. EvoDevo. 12:4
- Gu, L., Tian, L., Gao, G., Peng, S., Zhang, J., Wu, D., Huang, J., Hua, Q., Lu, T., Zhong, L., Fu, Z., Pan, X., Qian, H., Sun, L. (2020) Inhibitory effects of polystyrene microplastics on caudal fin regeneration in zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 266:114664
- Ye, Z., Su, Z., Xie, S., Liu, Y., Wang, Y., Xu, X., Zheng, Y., Zhao, M., Jiang, L. (2020) Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration. eLIFE. 9:
- Brandão, A.S., Bensimon-Brito, A., Lourenço, R., Borbinha, J., Soares, A.R., Jacinto, A. (2019) Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration. Journal of Cell Science. 132(22):
- Garland, M.A., Sengupta, S., Mathew, L.K., Truong, L., de Jong, E., Piersma, A.H., La Du, J., Tanguay, R.L. (2019) Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration. Toxicology reports. 6:529-537
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