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ZIRC
ZFIN ID: ZDB-GENE-990415-269
Gene Name: alpha-tropomyosin
Gene Symbol: tpma    Nomenclature History

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Previous Names: tm, fb37a09, TPM1-2 alpha (1), tropomyosin alpha chain, wu:fb37a09 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in myeloid cell development. Predicted to localize to the actin filament. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Is expressed in adaxial cell; male organism; musculature system; pericardial region; and somite. Orthologous to human TPM1 (tropomyosin 1).
Genome Resources: Alliance (1),  Gene:30324 (1),  Ensembl(GRCz11):ENSDARG00000033683 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-tpma N/A 1
PHENOTYPE
Data: Fig. 2 from Gieger et al., 2011
Observed in:
DISEASE ASSOCIATED WITH tpma HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH tpma VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process myeloid cell development (more)
Cellular Component actin cytoskeleton (more)
Molecular Function actin filament binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000533 (1)
  • InterPro:IPR042180 (1)
  • PROSITE:PS00326 (1)
  • Pfam:PF00261 (1)
  • Pfam:PF12718 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tpma-001 (1) 1618
    tpma-002 (1) 1407
    tpma-201 (1)    Ensembl 812
    tpma-202 (1)    Ensembl 3089
    tpma-203 (1)    Ensembl 529
    tpma-204 (1)    Ensembl 721
    tpma-205 (1)    Ensembl 487
    tpma-206 (1)    Ensembl 402
    tpma-207 (1)    Ensembl 631
    tpma-208 (1)    Ensembl 751
    tpma-209 (1)    Ensembl 753
    tpma-210 (1)    Ensembl 639
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tpma
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-4.0tpma:EGFP) tpma EGFP Danio rerio 1 3
    Tg(tpma:KALTA4,4xUAS:EGFP) tpmaUAS EGFPKALTA4 Danio rerio 1 1
    MARKER RELATIONSHIPS
    tpma Contained in: [BAC] CH73-148P15 (1) (order this)
    [PAC] BUSM1-132M23 (order this)
    tpma Encodes: [EST] fb37a09 (1)
    [cDNA] MGC:77897 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131105 (1) 1406 bp
    Genomic GenBank:AL845510 (1) 101241 bp
    Select Tool
    Polypeptide UniProtKB:P13104 (1) 284 aa
    Sequence Clusters UniGene:47559 (1)
    Sequence Information (all 34)
    ORTHOLOGY for tpma ( Chr: 7 )
    CITATIONS (76)