Gene
rxrbb
- ID
- ZDB-GENE-990415-242
- Name
- retinoid x receptor, beta b
- Symbol
- rxrbb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in blastoderm; ovary; and testis. Orthologous to human RXRB (retinoid X receptor beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- u29941 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027690Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR021780 | Nuclear/hormone receptor activator site AF-1 |
| Family | IPR000003 | Retinoid X receptor/HNF4 |
| Family | IPR001723 | Nuclear hormone receptor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear/hormone receptor activator site AF-1 | Nuclear hormone receptor family NR2 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Retinoid X receptor/HNF4 | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DG77 | InterPro | 422 | ||||||||
| UniProtKB:Q90417 | InterPro | 422 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-79G6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-73G17 | ZFIN Curated Data | |
| Encodes | EST | u29941 | Bertrand et al., 2007 | |
| Encodes | cDNA | MGC:193904 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193905 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131238 (1) | 1506 nt | ||
| Genomic | GenBank:CR848674 (1) | 149652 nt | ||
| Polypeptide | UniProtKB:B3DG77 (1) | 422 aa |
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Aman, A.J., Kim, M., Saunders, L.M., Parichy, D.M. (2021) Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development. Developmental Biology. 477:205-218
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
- Tao, J., Bai, C., Chen, Y., Zhou, H., Liu, Y., Shi, Q., Pan, W., Dong, H., Li, L., Xu, H., Tanguay, R., Huang, C., Dong, Q. (2020) Environmental relevant concentrations of benzophenone-3 induced developmental neurotoxicity in zebrafish. The Science of the total environment. 721:137686
- Walter, K.M., Miller, G.W., Chen, X., Yaghoobi, B., Puschner, B., Lein, P.J. (2018) Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio). General and comparative endocrinology. 272:20-32
- Wu, Y., Su, G., Tang, S., Liu, W., Ma, Z., Zheng, X., Liu, H., Yu, H. (2017) The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere. 168:122-130
- Cunha, V., Rodrigues, P., Santos, M.M., Moradas-Ferreira, P., Ferreira, M. (2016) Danio rerio embryos on Prozac - Effects on the detoxification mechanism and embryo development. Aquatic toxicology (Amsterdam, Netherlands). 178:182-189
- Cheng, Y.Y., Tao, W.J., Chen, J.L., Sun, L.N., Zhou, L.Y., Song, Q., Wang, D.S. (2015) Genome-wide identification, evolution and expression analysis of nuclear receptor superfamily in Nile tilapia, Oreochromis niloticus. Gene. 569(1):141-52
- Zhao, Y., Zhang, K., Giesy, J.P., Hu, J. (2015) Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective. Scientific Reports. 5:8554
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