Gene

pou4f3

ID

ZDB-GENE-990415-24

Name

POU class 4 homeobox 3

Symbol

pou4f3 Nomenclature History

Previous Names

brn-3c (1)
brn3.1
brn3c (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in brain development. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15 and autosomal dominant nonsyndromic deafness 52. Is expressed in auditory receptor cell. Orthologous to human POU4F3 (POU class 4 homeobox 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pou4f3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 15	Alliance	Deafness, autosomal dominant 15/52	602459

Associated With pou4f3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR000327	POU-specific domain
Domain	IPR001356	Homeodomain
Domain	IPR013847	POU domain
Family	IPR050255	POU domain transcription factor
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR010982	Lambda repressor-like, DNA-binding domain superfamily