ZFIN ID: ZDB-GENE-990415-24
Gene Name: POU class 4 homeobox 3
Gene Symbol: pou4f3    Nomenclature History

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Previous Names: brn-3c (1), brn3.1, brn3c (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in brain development. Predicted to localize to cytoplasm and nucleus. Is expressed in auditory receptor cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15 and autosomal dominant nonsyndromic deafness 52. Orthologous to human POU4F3 (POU class 4 homeobox 3).
Genome Resources: Alliance (1),  Gene:30534 (1),  Ensembl(GRCz11):ENSDARG00000006206 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-pou4f3
4
CRISPR2-pou4f3
2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH pou4f3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 15 Alliance Deafness, autosomal dominant 15 602459
DISEASE ASSOCIATED WITH pou4f3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process brain development (more)
Cellular Component cytoplasm (more)
Molecular Function sequence-specific DNA binding (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pou4f3-201 (1)    Ensembl 996
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pou4f3
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(pou4f3:ctbp2l-mKOFP) pou4f3 ctbp2lmKOFP Danio rerio 1 4
Tg(pou4f3:GAL4) pou4f3 GAL4 Danio rerio 1 9
Tg(pou4f3:GAL4,UAS:GAP-GFP) pou4f3 GAL4GFP Danio rerio 2 23
Tg(pou4f3:GAL4-VP16) pou4f3 GAL4VP16 Danio rerio 1 1
Tg(pou4f3:GAL80,myl7:EGFP) myl7pou4f3 EGFPGAL80 Danio rerio 1 2
Tg(pou4f3:GAP-GFP) pou4f3 GFP Danio rerio 2 155
MARKER RELATIONSHIPS
pou4f3 Contained in: [BAC] DKEY-149G3 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131278 (1) 996 nt
Genomic GenBank:CU468941 (1) 64865 nt
Select Tool
Polypeptide UniProtKB:Q90435 (1) 331 aa
Sequence Information (all 10)
ORTHOLOGY for pou4f3 ( Chr: 9 )
CITATIONS (41)