Gene
fzd3a
- ID
- ZDB-GENE-990415-225
- Name
- frizzled class receptor 3a
- Symbol
- fzd3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within anterior/posterior axon guidance; commissural neuron axon guidance; and facial nucleus development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; neural plate; neural tube; neurons; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and schizophrenia. Orthologous to human FZD3 (frizzled class receptor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu713 (1 image)
- eu1591 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013873Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la013874Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021595Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| rw689 | Allele with one point mutation | Unknown | Missense | not specified | |
| sa8665 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37109 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sdu21 | Allele with one delins | Exon 4 | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fzd3a | N/A | (3) |
| MO2-fzd3a | N/A | Hofmeister et al., 2012 |
| MO3-fzd3a | N/A | (2) |
| TALEN1-fzd3a | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000539 | Frizzled/Smoothened, 7TM |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Domain | IPR020067 | Frizzled domain |
| Domain | IPR041769 | Frizzled 3, cysteine-rich domain |
| Family | IPR015526 | Frizzled/secreted frizzled-related protein |
| Homologous_superfamily | IPR036790 | Frizzled cysteine-rich domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Frizzled 3, cysteine-rich domain | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Frizzled/Smoothened, 7TM | GPCR, family 2-like, 7TM |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5TZ38 | InterPro | 685 | ||||||
| UniProtKB:A0A8M2B7P5 | InterPro | 686 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(10xUAS:fzd3a-GFP) |
|
| 1 | (3) | |
| Tg(UAS:dnfzd3a-RFP) |
|
| 1 | Iwasaki et al., 2018 | |
| Tg(UAS:fzd3a-mEos) |
|
| 1 | Mathewson et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-89P3 | ZFIN Curated Data | |
| Encodes | EST | eu713 | Thisse et al., 2005 | |
| Encodes | EST | eu1591 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:174969 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194938 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194968 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001042761 (1) | 2908 nt | ||
| Genomic | GenBank:BX511007 (1) | 174463 nt | ||
| Polypeptide | UniProtKB:A0A8M2B7P5 (1) | 686 aa |
- Meserve, J.H., Navarro, M.F., Ortiz, E.A., Granato, M. (2024) Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit. PLoS Genetics. 20:e1011415e1011415
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Asante, E., Hummel, D., Gurung, S., Kassim, Y.M., Al-Shakarji, N., Palaniappan, K., Sittaramane, V., Chandrasekhar, A. (2021) Defective Neuronal Positioning Correlates With Aberrant Motor Circuit Function in Zebrafish. Frontiers in neural circuits. 15:690475
- Menon, T., Borbora, A.S., Kumar, R., Nair, S. (2020) Dynamic optima in cell sizes during early development enable normal gastrulation in zebrafish embryos. Developmental Biology. 468(1-2):26-40
- Zhao, W., Yuan, P., Hu, N., Long, D., Ding, D., Wang, H. (2020) Effects of Low-Dose Gamma-Ray Radiation on Apoptosis and Development of Zebrafish Embryo Brain. Radiation Research. 194(1):61-70
- Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730
- Kamei, C.N., Gallegos, T.F., Liu, Y., Hukriede, N., Drummond, I.A. (2019) Wnt signaling mediates new nephron formation during zebrafish kidney regeneration. Development (Cambridge, England). 146(8):
- Mathewson, A.W., Berman, D., Moens, C.B. (2019) Microtubules are required for the maintenance of planar cell polarity in monociliated floorplate cells. Developmental Biology. 452(1):21-33
- Iwasaki, M., Kuroda, J., Kawakami, K., Wada, H. (2018) Epidermal regulation of bone morphogenesis through the development and regeneration of osteoblasts in the zebrafish scale. Developmental Biology. 437(2):105-119
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