Gene

fzd2

ID
ZDB-GENE-990415-224
Name
frizzled class receptor 2
Symbol
fzd2 Nomenclature History
Previous Names
  • fz-2 (1)
  • fz2 (1)
  • fz8
  • cb383 (1)
  • wu:fb70g09
  • zg08
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in several processes, including Wnt signaling pathway, calcium modulating pathway; heart development; and sensory epithelium regeneration. Localizes to plasma membrane. Is expressed in several structures, including cardiovascular system; fin; head; head mesenchyme; and mesoderm. Human ortholog(s) of this gene implicated in omodysplasia. Orthologous to human FZD2 (frizzled class receptor 2).
Genome Resources
Note
None
Expression
All Expression Data
18 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fzd2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
omodysplasia Alliance Omodysplasia 2 164745
Associated With fzd2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000539 Frizzled/Smoothened, transmembrane domain
Domain IPR017981 GPCR, family 2-like
Domain IPR020067 Frizzled domain
Family IPR015526 Frizzled/secreted frizzled-related protein
Family IPR026550 Frizzled-2
Homologous_superfamily IPR036790 Frizzled cysteine-rich domain superfamily
Domain Details Per Protein
Protein Length Frizzled-2 Frizzled cysteine-rich domain superfamily Frizzled domain Frizzled/secreted frizzled-related protein Frizzled/Smoothened, transmembrane domain GPCR, family 2-like
UniProtKB:Q90449 123
UniProtKB:F1QBI2 550
UniProtKB:Q90YL7 550
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations