Gene

fzd2

ID
ZDB-GENE-990415-224
Name
frizzled class receptor 2
Symbol
fzd2 Nomenclature History
Previous Names
  • fz-2 (1)
  • fz2 (1)
  • fz8
  • cb383 (1)
  • wu:fb70g09
  • zg08
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in several processes, including Wnt signaling pathway, calcium modulating pathway; heart development; and sensory epithelium regeneration. Localizes to plasma membrane. Is expressed in several structures, including cardiovascular system; fin; head; head mesenchyme; and mesoderm. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fzd2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
omodysplasia 2 Alliance Omodysplasia 2 164745
Associated With fzd2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000539 Frizzled/Smoothened, transmembrane domain
Domain IPR017981 GPCR, family 2-like
Domain IPR020067 Frizzled domain
Family IPR015526 Frizzled/secreted frizzled-related protein
Family IPR026550 Frizzled-1/2
Homologous_superfamily IPR036790 Frizzled cysteine-rich domain superfamily
Domain Details Per Protein
Protein Length Frizzled-1/2 Frizzled cysteine-rich domain superfamily Frizzled domain Frizzled/secreted frizzled-related protein Frizzled/Smoothened, transmembrane domain GPCR, family 2-like
UniProtKB:F1QBI2 550
UniProtKB:Q90449 123
UniProtKB:Q90YL7 550
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations