ZFIN ID: ZDB-GENE-990415-176
Gene Name: nerve growth factor a (beta polypeptide)
Gene Symbol: ngfa    Nomenclature History

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Previous Names: etID309941.23 (1), nt7, ntf6/7 (1), ntf7, znt7

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; nervous system development; and positive regulation of peptidyl-serine phosphorylation. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in otic vesicle. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor).
Genome Resources: Alliance (1),  Gene:30270 (1),  Ensembl(GRCz11):ENSDARG00000058961 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014470Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ngfa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary sensory and autonomic neuropathy type 5 Alliance Neuropathy, hereditary sensory and autonomic, type V 608654
    DISEASE ASSOCIATED WITH ngfa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process memory (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ngfa-202 (1)    Ensembl 1015
    ngfa-203 (1)    Ensembl 948
    ngfa-204 (1)    Ensembl 957
    ngfa-205 (1)    Ensembl 1079
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ngfa No data available
    MARKER RELATIONSHIPS
    ngfa Contained in: [BAC] CH211-117K14 (1)
    ngfa Encodes: [cDNA] MGC:193882 (1), MGC:193891 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131064 (1) 1238 nt
    Genomic GenBank:CR354596 (1) 172749 nt
    Select Tool
    Polypeptide UniProtKB:B3DG61 (1) 233 aa
    Sequence Information (all 41)
    ORTHOLOGY for ngfa ( Chr: 23 )
    CITATIONS (34)