ZFIN is now using GRCz12tu for Genomic Data
Gene
ngfa
- ID
- ZDB-GENE-990415-176
- Name
- nerve growth factor a (beta polypeptide)
- Symbol
- ngfa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of neuron apoptotic process; and nervous system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space and synaptic vesicle. Is expressed in otic vesicle. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and opiate dependence (multiple). Orthologous to human NGF (nerve growth factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary sensory and autonomic neuropathy type 5 | Alliance | Neuropathy, hereditary sensory and autonomic, type V | 608654 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Nerve growth factor conserved site | Nerve growth factor-like | Nerve growth factor-related |
|---|---|---|---|---|---|---|
| UniProtKB:O73797 | InterPro | 233 | ||||
| UniProtKB:A0A8M3AY43 | InterPro | 281 | ||||
| UniProtKB:B3DG61 | InterPro | 233 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ngfa-201
(1)
|
Ensembl | 1,021 nt | ||
| mRNA |
ngfa-202
(1)
|
Ensembl | 1,015 nt | ||
| mRNA |
ngfa-203
(1)
|
Ensembl | 948 nt | ||
| mRNA |
ngfa-204
(1)
|
Ensembl | 957 nt | ||
| mRNA |
ngfa-205
(1)
|
Ensembl | 1,079 nt | ||
| mRNA |
ngfa-206
(1)
|
Ensembl | 1,238 nt | ||
| mRNA |
ngfa-207
(1)
|
Ensembl | 788 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers