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Gene

nras

ID
ZDB-GENE-990415-166
Name
NRAS proto-oncogene, GTPase
Symbol
nras Nomenclature History
Previous Names
  • etID18709.8 (1)
  • fj99a10
  • wu:fj99a10 (1)
  • zgc:100761
  • zras-b1 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in Golgi membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; liver; pleuroperitoneal region; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nras Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autoimmune lymphoproliferative syndrome type 4 Alliance ?RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic 614470
colorectal cancer Alliance Colorectal cancer, somatic 114500
epidermal nevus Alliance Epidermal nevus, somatic 162900
large congenital melanocytic nevus Alliance Melanocytic nevus syndrome, congenital, somatic 137550
linear nevus sebaceous syndrome Alliance Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200
Noonan syndrome 6 Alliance Noonan syndrome 6 613224
thyroid gland follicular carcinoma Alliance Thyroid carcinoma, follicular, somatic 188470
Neurocutaneous melanosis, somatic 249400
Associated With nras Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Family IPR001806 Small GTPase
Family IPR020849 Small GTPase superfamily, Ras-type
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length P-loop containing nucleoside triphosphate hydrolase Small GTPase Small GTPase superfamily, Ras-type Small GTP-binding protein domain
UniProtKB:P79737 188
UniProtKB:Q6DGD1 188
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations