Gene

mstnb

ID

ZDB-GENE-990415-165

Name

myostatin b

Symbol

mstnb Nomenclature History

Previous Names

mstn-1 (1)
mstn
gdf8 (1)
zgc:109749

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Exhibits growth factor activity. Involved in several processes, including muscle organ development; negative regulation of cardiac muscle myoblast proliferation; and negative regulation of growth rate. Predicted to localize to extracellular space. Is expressed in several structures, including digestive system; heart; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Orthologous to human MSTN (myostatin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

23 figures from 19 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109749 (1 image)
eu171 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mstnb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Muscle hypertrophy	614160

Associated With mstnb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine