Gene

dlx4a

ID

ZDB-GENE-980526-73

Name

distal-less homeobox 4a

Symbol

dlx4a Nomenclature History

Previous Names

dlx8

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; embryonic skeletal system development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in dental papilla; gill; and head. Human ortholog(s) of this gene implicated in orofacial cleft 15. Orthologous to human DLX4 (distal-less homeobox 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu468 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dlx4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
orofacial cleft 15	Alliance	?Orofacial cleft 15	616788

Associated With dlx4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Family	IPR050460	Distal-less homeobox transcription factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily