ZFIN ID: ZDB-GENE-980526-487
Gene Name: complement factor B
Gene Symbol: cfb    Nomenclature History

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Previous Names: Bf-1 (1), bf (1), Brre-Bf (1), zgc:114032

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase activity. Involved in response to bacterium. Predicted to localize to the extracellular region. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); glomerulonephritis (multiple); precursor lymphoblastic lymphoma/leukemia; and sickle cell anemia. Is expressed in liver. Orthologous to human CFB (complement factor B).
Genome Resources: Alliance (1),  Gene:30604 (1),  Ensembl(GRCz11):ENSDARG00000055278 (1)
GENE EXPRESSION
All Expression Data: 8 figures from 7 publications
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1866 Point Mutation Unknown Premature Stop ENU
sa14271 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23958 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29609 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cfb
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cfb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    age related macular degeneration 14 Alliance {Macular degeneration, age-related, 14, reduced risk of} 615489
    ?Complement factor B deficiency 615561
    {Hemolytic uremic syndrome, atypical, susceptibility to, 4} 612924
    DISEASE ASSOCIATED WITH cfb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to bacterium (more)
    Cellular Component extracellular region (more)
    Molecular Function serine-type endopeptidase activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000436 Sushi/SCR/CCP domain
    Domain IPR001254 Serine proteases, trypsin domain
    Family IPR001314 Peptidase S1A, chymotrypsin family
    Domain IPR002035 von Willebrand factor, type A
    Homologous_superfamily IPR009003 Peptidase S1, PA clan
    Family IPR011360 Complement B/C2
    Active_site IPR018114 Serine proteases, trypsin family, histidine active site
    Homologous_superfamily IPR035976 Sushi/SCR/CCP superfamily
    Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cfb-201 (1)    Ensembl 2433
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cfb No data available
    MARKER RELATIONSHIPS
    cfb Contained in: [BAC] DKEY-197A18 (1) (order this)
    cfb Encodes: [cDNA] MGC:114032 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131338 (1) 2409 bp
    Genomic GenBank:BX511175 (1) 134295 bp
    Select Tool
    Polypeptide UniProtKB:F1R886 (1) 761 aa
    Sequence Information (all 25)
    ORTHOLOGY for cfb ( Chr: 21 )
    CITATIONS (45)