Gene

cbfb

ID
ZDB-GENE-980526-440
Name
core-binding factor subunit beta
Symbol
cbfb Nomenclature History
Previous Names
  • unp1266
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Exhibits protein heterodimerization activity. Contributes to DNA binding activity and transcription coregulator activity. Involved in several processes, including heart contraction; lymphoid lineage cell migration into thymus; and myofibril assembly. Localizes to Z disc and core-binding activity factor complex. Is expressed in several structures, including digestive system; ganglia; hematopoietic system; immune system; and pericardial region. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CBFB (core-binding factor subunit beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cbfb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance Myeloid leukemia, acute, M4/M4Eo subtype, somatic 601626
Associated With cbfb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR003417 Core-binding factor, beta subunit
Homologous_superfamily IPR036552 Core-binding factor, beta subunit superfamily
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cbfb polyclonal Rabbit
Abcam plc
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations