Gene
cahz
- ID
- ZDB-GENE-980526-39
- Name
- carbonic anhydrase
- Symbol
- cahz Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables carbonate dehydratase activity. Acts upstream of or within carbon dioxide transport and hypotonic salinity response. Predicted to be active in cytoplasm. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; pleuroperitoneal region; and presumptive blood. Human ortholog(s) of this gene implicated in alcoholic pancreatitis; autoimmune disease (multiple); osteopetrosis (multiple); and viral hepatitis. Orthologous to several human genes including CA2 (carbonic anhydrase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb588 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gilmour et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa32934 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive osteopetrosis 3 | Alliance | Osteopetrosis, autosomal recessive 3, with renal tubular acidosis | 259730 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha carbonic anhydrase domain | Alpha carbonic anhydrase domain superfamily | Carbonic anhydrase, alpha-class | Carbonic anhydrase, alpha-class, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:Q92051 | InterPro | 260 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-121G18 | ZFIN Curated Data | |
| Encodes | EST | cb588 | Thisse et al., 2001 | |
| Encodes | EST | cegs2190 | (2) | |
| Encodes | EST | fj65c09 | ZFIN Curated Data | |
| Encodes | EST | ibd5016 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77128 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131110 (1) | 1574 nt | ||
| Genomic | GenBank:BX927106 (2) | 147604 nt | ||
| Polypeptide | UniProtKB:Q92051 (1) | 260 aa |
- Dong, H., Mao, L., Bai, C., Ye, K., Wu, H., Lei, Y., Yu, S., Liu, Y., Tao, J., Pan, W., Xu, H., Lin, J., Zhu, J., Dong, Q. (2022) Characterization of Developmental Neurobehavioral Toxicity in a Zebrafish MPTP-Induced Model: A Novel Mechanism Involving Anemia. ACS Chemical Neuroscience. 13(13):1877-1890
- Babić, S., Čižmek, L., Maršavelski, A., Malev, O., Pflieger, M., Strunjak-Perović, I., Popović, N.T., Čož-Rakovac, R., Trebše, P. (2021) Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires. Scientific Reports. 11:2527
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Ayobahan, S.U., Eilebrecht, S., Baumann, L., Teigeler, M., Hollert, H., Kalkhof, S., Eilebrecht, E., Schäfers, C. (2020) Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Chemosphere. 240:124970
- Raj, B., Farrell, J.A., Liu, J., El Kholtei, J., Carte, A.N., Navajas Acedo, J., Du, L.Y., McKenna, A., Relić, Đ., Leslie, J.M., Schier, A.F. (2020) Emergence of Neuronal Diversity during Vertebrate Brain Development. Neuron. 108(6):1058-1074.e6
- Zhou, Z.Y., Zhao, W.R., Xiao, Y., Zhang, J., Tang, J.Y., Lee, S.M. (2020) Mechanism Study of the Protective Effects of Sodium Tanshinone IIA Sulfonate Against Atorvastatin-Induced Cerebral Hemorrhage in Zebrafish: Transcriptome Analysis. Frontiers in pharmacology. 11:551745
- Han, J., Liu, K., Wang, R., Zhang, Y., Zhou, B. (2019) Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 214:105236
- Greenhough, A., Bagley, C., Heesom, K.J., Gurevich, D.B., Gay, D., Bond, M., Collard, T.J., Paraskeva, C., Martin, P., Sansom, O.J., Malik, K., Williams, A.C. (2018) Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO Molecular Medicine. 10(11):
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
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