Gene
evx1
- ID
- ZDB-GENE-980526-364
- Name
- even-skipped homeobox 1
- Symbol
- evx1 Nomenclature History
- Previous Names
-
- cb416 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic skeletal joint development; fin morphogenesis; and ventral spinal cord interneuron specification. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; fin; gut; neural tube; and pronephros. Orthologous to human EVX1 (even-skipped homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 46 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb416 (36 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| i232 | Allele with one point mutation | Exon 2 | Premature Stop | ENU | |
| la020638Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa36819 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Even-skipped homeobox domain-containing protein | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IVI8 | InterPro | 377 | |||||
| UniProtKB:A0AB32T874 | InterPro | 252 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-25E11 | ZFIN Curated Data | |
| Encodes | EST | cb416 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131249 (1) | 2401 nt | ||
| Genomic | GenBank:CR382300 (1) | 202006 nt | ||
| Polypeptide | UniProtKB:A0A0R4IVI8 (1) | 377 aa |
- Comparative Orthology
- Alliance
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Seaver, A.W., Weaver, N.S., Iovine, M.K. (2023) Retinoic Acid Influences connexin43 Expression During Joint Formation in the Regenerating Zebrafish Fin. Bioelectricity. 5:173180173-180
- Wang, H., Zaiser, F., Eckert, P., Ruf, J., Kayser, N., Veenstra, A.C., Müller, M., Haas, R., Walz, G., Yakulov, T.A. (2023) Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation. Biochemical and Biophysical Research Communications. 673:9159-15
- Hevia, C.F., Engel-Pizcueta, C., Udina, F., Pujades, C. (2022) The neurogenic fate of the hindbrain boundaries relies on Notch3-dependent asymmetric cell divisions. Cell Reports. 39:110915
- Bhattacharya, S., Hyland, C., Falk, M.M., Iovine, M.K. (2020) Connexin43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins. Development (Cambridge, England). 147(13):
- England, S.J., Cerda, G.A., Kowalchuk, A., Sorice, T., Grieb, G., Lewis, K.E. (2020) Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development. Genetics. 216(4):1153-1185
- Mao, A., Zhang, M., Li, L., Liu, J., Ning, G., Cao, Y., Wang, Q. (2020) Pharyngeal pouches provide a niche microenvironment for arch artery progenitor specification. Development (Cambridge, England). 148(2):
- Rieke, J.M., Zhang, R., Braun, D., Yilmaz, Ö., Japp, A.S., Lopes, F.M., Pleschka, M., Hilger, A.C., Schneider, S., Newman, W.G., Beaman, G.M., Nordenskjöld, A., Ebert, A.K., Promm, M., Rösch, W.H., Stein, R., Hirsch, K., Schäfer, F.M., Schmiedeke, E., Boemers, T.M., Lacher, M., Kluth, D., Gosemann, J.H., Anderberg, M., Barker, G., Holmdahl, G., Läckgren, G., Keene, D., Cervellione, R.M., Giorgio, E., Di Grazia, M., Feitz, W.F.J., Marcelis, C.L.M., Van Rooij, I.A.L.M., Bökenkamp, A., Beckers, G.M.A., Keegan, C.E., Sharma, A., Dakal, T.C., Wittler, L., Grote, P., Zwink, N., Jenetzky, E., Brusco, A., Thiele, H., Ludwig, M., Schweizer, U., Woolf, A.S., Odermatt, B., Reutter, H. (2020) SLC20A1 Is Involved in Urinary Tract and Urorectal Development. Frontiers in cell and developmental biology. 8:567
- Ghersi, J.J., Mahony, C.B., Bertrand, J.Y. (2019) bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish. Development (Cambridge, England). 146(6):
- Hadjivasiliou, Z., Moore, R.E., McIntosh, R., Galea, G.L., Clarke, J.D.W., Alexandre, P. (2019) Basal Protrusions Mediate Spatiotemporal Patterns of Spinal Neuron Differentiation. Developmental Cell. 49:907-919.e10
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