Gene
flt4
- ID
- ZDB-GENE-980526-326
- Name
- fms related receptor tyrosine kinase 4
- Symbol
- flt4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; regulation of signal transduction; and vasculature development. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including angioblastic mesenchymal cell; brain; mesoderm; vascular cord; and vasculature. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 164 figures from 128 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1059 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 37 figures from 18 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu4602 | Allele with one point mutation | Unknown | Missense | not specified | |
| ihb438 | Allele with one insertion | Exon 13 | Unknown | CRISPR | |
| ihb439 | Allele with one deletion | Exon 13 | Unknown | CRISPR | |
| la027502Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mu407 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa281 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9798 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16036 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30675 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31980 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-flt4 | He et al., 2015 | |
| CRISPR2-flt4 | (2) | |
| CRISPR3-flt4 | Klems et al., 2020 | |
| CRISPR4-flt4 | Green et al., 2022 | |
| CRISPR5-flt4 | Green et al., 2022 | |
| MO1-flt4 | N/A | (11) |
| MO2-flt4 | N/A | Covassin et al., 2006 |
| MO3-flt4 | N/A | (23) |
| TALEN1-flt4 | Gupta et al., 2013 | |
| TALEN2-flt4 | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary lymphedema IA | Alliance | Lymphatic malformation 1 | 153100 |
| Congenital heart defects, multiple types, 7 | 618780 | ||
| Hemangioma, capillary infantile, somatic | 602089 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like beta-sandwich domain | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class III, conserved site | VEGFR1-3, fifth immunoglobulin-like domain | VEGFR1-3, N-terminal Ig-like domain | VEGFR-2, transmembrane domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5MD89 | InterPro | 1357 | ||||||||||||||||||
| UniProtKB:A0A8M3AZL8 | InterPro | 1364 | ||||||||||||||||||
| UniProtKB:A0A0R4IFS9 | InterPro | 1368 | ||||||||||||||||||
| UniProtKB:A0A2R8QSE0 | InterPro | 1324 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(flt4:Citrine) |
|
| 1 | (30) | |
| Tg(fli1:flt4-2A-mCherry) |
| 1 | Davis et al., 2018 | ||
| Tg(flt4:YFP) |
|
| 1 | (7) | |
| Tg(hsp70l:flt4,cryaa:Cerulean) |
|
| 1 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198F4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-58G10 | ZFIN Curated Data | |
| Encodes | EST | cb1059 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130945 (1) | 4456 nt | ||
| Genomic | GenBank:CR381700 (1) | 203630 nt | ||
| Polypeptide | UniProtKB:A0A0R4IFS9 (1) | 1368 aa |
- Fernezelian, D., Pfitsch, S., Rastegar, S., Diotel, N. (2024) Mapping the cellular expression patterns of vascular endothelial growth factor aa and bb genes and their receptors in the adult zebrafish brain during constitutive and regenerative neurogenesis. Neural Development. 19:1717
- Monaghan, R.M., Naylor, R.W., Flatman, D., Kasher, P.R., Williams, S.G., Keavney, B.D. (2024) FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms. Cardiovascular research. 120(10):1164-1176
- Veloso, A., Bleuart, A., Conrard, L., Orban, T., Bruyr, J., Cabochette, P., Germano, R.F.V., Schevenels, G., Bernard, A., Zindy, E., Demeyer, S., Vanhollebeke, B., Dequiedt, F., Martin, M. (2024) The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish. BMC Biology. 22:5151
- Yu, T., Chen, J., Wang, Y., Xu, J. (2024) The embryonic zebrafish brain is exclusively colonized by pu.1-dependent and lymphatic-independent population of microglia. Science advances. 10:eado0519
- Zhang, J.L., Fan, D.G., Yin, W., Hu, B. (2024) CM082 suppresses hypoxia-induced retinal neovascularization in larval zebrafish. Frontiers in pharmacology. 15:13362491336249
- Zhou, W., Ghersi, J.J., Ristori, E., Semanchik, N., Prendergast, A., Zhang, R., Carneiro, P., Baldissera, G., Sessa, W.C., Nicoli, S. (2024) Akt is a mediator of artery specification during zebrafish development. Development (Cambridge, England). 151(17):
- Gafranek, J.T., D'Aniello, E., Ravisankar, P., Thakkar, K., Vagnozzi, R.J., Lim, H.W., Salomonis, N., Waxman, J.S. (2023) Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart. Nature communications. 14:55095509
- Hipke, K., Pitter, B., Hruscha, A., van Bebber, F., Modic, M., Bansal, V., Lewandowski, S.A., Orozco, D., Edbauer, D., Bonn, S., Haass, C., Pohl, U., Montanez, E., Schmid, B. (2023) Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. Frontiers in cell and developmental biology. 11:11699621169962
- Parab, S., Card, O.A., Chen, Q., America, M., Buck, L.D., Quick, R.E., Horrigan, W.F., Levkowitz, G., Vanhollebeke, B., Matsuoka, R.L. (2023) Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries. eLIFE. 12:
- Wang, Y.S., Chen, Y.T., Wu, C.Y. (2023) Functional characterization of stap2b in zebrafish vascular development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e23053e23053
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