ZFIN is now using GRCz12tu for Genomic Data
Gene
flt4
- ID
- ZDB-GENE-980526-326
- Name
- fms related receptor tyrosine kinase 4
- Symbol
- flt4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables identical protein binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; regulation of signal transduction; and vasculature development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including angioblastic mesenchymal cell; brain; mesoderm; vascular cord; and vasculature. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 164 figures from 128 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1059 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 37 figures from 18 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary lymphedema IA | Alliance | Lymphatic malformation 1 | 153100 |
| Congenital heart defects, multiple types, 7 | 618780 | ||
| Hemangioma, capillary infantile, somatic | 602089 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013151 | Immunoglobulin-like beta-sandwich domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041348 | VEGFR-2, transmembrane domain |
| Domain | IPR055229 | VEGFR1-3, fifth immunoglobulin-like domain |
| Domain | IPR055238 | VEGFR1-3, N-terminal Ig-like domain |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like beta-sandwich domain | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class III, conserved site | VEGFR1-3, fifth immunoglobulin-like domain | VEGFR1-3, N-terminal Ig-like domain | VEGFR-2, transmembrane domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5MD89 | InterPro | 1357 | ||||||||||||||||||
| UniProtKB:A0A8M3AZL8 | InterPro | 1364 | ||||||||||||||||||
| UniProtKB:A0A0R4IFS9 | InterPro | 1368 | ||||||||||||||||||
| UniProtKB:A0A2R8QSE0 | InterPro | 1324 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers