ZFIN ID: ZDB-GENE-980526-135
Gene Name: Indian hedgehog signaling molecule b
Gene Symbol: ihhb    Nomenclature History

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Previous Names: ehh (1), hh[b] (1), hhb, echidna hedgehog, zgc:113262

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and patched binding activity. Involved in oligodendrocyte differentiation; regulation of oligodendrocyte progenitor proliferation; and striated muscle cell development. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; and retinopathy of prematurity. Is expressed in axis; central nervous system; cranium; gut; and notochord. Orthologous to human IHH (Indian hedgehog signaling molecule).
Genome Resources: Alliance (1),  Gene:30299 (1),  Ensembl(GRCz11):ENSDARG00000058815 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20623 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ihhb N/A 4
    MO2-ihhb N/A 3
    MO3-ihhb N/A 1
    DISEASE ASSOCIATED WITH ihhb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acrocapitofemoral dysplasia Alliance Acrocapitofemoral dysplasia 607778
    brachydactyly type A1 Alliance Brachydactyly, type A1 112500
    DISEASE ASSOCIATED WITH ihhb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process striated muscle cell development (more)
    Cellular Component extracellular region (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ihhb-201 (1)    Ensembl 1717
    ihhb-202 (1)    Ensembl 979
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ihhb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:ihhb-mCherry) hsp70l ihhbmCherry Danio rerio 1 3
    MARKER RELATIONSHIPS
    ihhb Contained in: [BAC] CH211-237C6 (1)
    ihhb Contains: [SNP] rs3727945 (1), rs3727946 (1)
    ihhb Encodes: [cDNA] MGC:113262 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131088 (1) 1479 nt
    Genomic GenBank:CU655960 (1) 153771 nt
    Select Tool
    Polypeptide UniProtKB:F1R9L0 (1) 412 aa
    Sequence Information (all 22)
    ORTHOLOGY for ihhb ( Chr: 6 )
    CITATIONS (86)