Gene
ihhb
- ID
- ZDB-GENE-980526-135
- Name
- Indian hedgehog signaling molecule b
- Symbol
- ihhb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity and patched binding activity. Involved in oligodendrocyte differentiation; regulation of oligodendrocyte progenitor proliferation; and striated muscle cell development. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; and retinopathy of prematurity. Is expressed in axis; central nervous system; cranium; gut; and notochord. Orthologous to human IHH (Indian hedgehog signaling molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chung et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrocapitofemoral dysplasia | Alliance | Acrocapitofemoral dysplasia | 607778 |
| brachydactyly type A1 | Alliance | Brachydactyly, type A1 | 112500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000320 | Hedgehog, N-terminal signalling domain |
| Domain | IPR001767 | Hedgehog protein, Hint domain |
| Domain | IPR003586 | Hint domain C-terminal |
| Domain | IPR003587 | Hint domain N-terminal |
| Family | IPR001657 | Hedgehog protein |
| Family | IPR050387 | Hedgehog Signaling |
| Homologous_superfamily | IPR009045 | Hedgehog signalling/DD-peptidase zinc-binding domain superfamily |
| Homologous_superfamily | IPR036844 | Hint domain superfamily |
| PTM | IPR006141 | Intein N-terminal splicing region |
Domain Details Per Protein
| Protein | Length | Hedgehog, N-terminal signalling domain | Hedgehog protein | Hedgehog protein, Hint domain | Hedgehog Signaling | Hedgehog signalling/DD-peptidase zinc-binding domain superfamily | Hint domain C-terminal | Hint domain N-terminal | Hint domain superfamily | Intein N-terminal splicing region |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z104
|
197 | |||||||||
|
UniProtKB:Q98862
|
412 | |||||||||
|
UniProtKB:F1QTR5
|
206 |
Interactions and Pathways
Plasmids
No data available