ZFIN ID: ZDB-GENE-980526-114
Gene Name: deltaB
Gene Symbol: dlb    Nomenclature History

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Previous Names: deltab, etID309872.5 (1), sc:d0400

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have Notch binding activity. Involved in diencephalon development and midbrain development. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis. Is expressed in several structures, including adenohypophyseal placode; digestive system; ectoderm; nervous system; and neural plate. Orthologous to human DLL3 (delta like canonical Notch ligand 3).
Genome Resources: Alliance (1),  Gene:30141 (1),  Ensembl(GRCz11):ENSDARG00000004232 (2)
DISEASE ASSOCIATED WITH dlb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondylocostal dysostosis Alliance Spondylocostal dysostosis 1, autosomal recessive 277300
DISEASE ASSOCIATED WITH dlb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process diencephalon development (more)
Cellular Component integral component of membrane (more)
Molecular Function calcium ion binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain IPR000742 EGF-like domain
Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
Domain IPR001881 EGF-like calcium-binding domain
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dlb-201 (1)    Ensembl 3030
ncRNA dlb-002 (1) 441
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dlb No data available
MARKER RELATIONSHIPS
dlb Contained in: [BAC] CH211-222C22 (1)
dlb Contains: [SNP] rs3727879 (1)
dlb Encodes: [EST] eu57 (1)
[cDNA] cssl:d400 (1), MGC:100773 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_130958 (1) 3007 bp
Genomic GenBank:BX005407 (1) 209796 bp Blast at MegaBLAST
Polypeptide UniProtKB:O57409 (1) 615 aa
Sequence Information (all 16)
ORTHOLOGY for dlb ( Chr: 5 )
CITATIONS (100)